Prediction of Passive Membrane Permeability and Translocation Pathways of Biologically Active Molecules
نویسندگان
چکیده
منابع مشابه
Outer-membrane translocation of bulky small molecules by passive diffusion.
The outer membrane (OM) of gram-negative bacteria forms a protective layer around the cell that serves as a permeability barrier to prevent unrestricted access of noxious substances. The permeability barrier of the OM results partly from the limited pore diameters of OM diffusion channels. As a consequence, there is an "OM size-exclusion limit," and the uptake of bulky molecules with molecular ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.2838